Introduction | Quick start: a runnable toy example | The planned design | Stage 1: assessing the clinically proposed truncation time | How can ($\tau = 24$) months be made feasible? | Approach 1: increase the additional follow-up period | Approach 2: select an earlier truncation time | Approach 3: increase the sample size | Customizing the hard-failure rules | Function "optimize_tau()": feasibility-constrained optimization | The complete two-stage workflow | Why is one table called the independent evaluation table?
Package: AHTauDesign 0.1.0
AHTauDesign: Truncation Time Selection for Average Hazard Analyses
Implements a two-stage, design-informed framework for selecting the truncation time in time-to-event trials analyzed with the average hazard estimand, motivated by pediatric oncology settings with small samples, slow accrual, and limited follow-up. Stage 1 validates a clinically proposed truncation time against the planned design using simulation-based diagnostics for risk-set support, follow-up coverage, estimability, and estimator stability, classifying it as Pass, Borderline, or Fail. Stage 2 performs constrained optimization over a grid of candidate truncation times within a clinical-distance window, maximizing a utility subject to feasibility constraints, with an independent evaluation run to assess the selected time. Supports proportional-hazards, early-, and delayed-effect patterns, uniform accrual with administrative censoring, and calibrated exponential random censoring.
Authors:
AHTauDesign_0.1.0.tar.gz
AHTauDesign_0.1.0.zip(r-4.7-any)AHTauDesign_0.1.0.zip(r-4.6-any)AHTauDesign_0.1.0.zip(r-4.5-any)
AHTauDesign_0.1.0.tgz(r-4.6-any)AHTauDesign_0.1.0.tgz(r-4.5-any)
AHTauDesign_0.1.0.tar.gz(r-4.7-any)AHTauDesign_0.1.0.tar.gz(r-4.6-any)
AHTauDesign_0.1.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION
card.svg |card.png
AHTauDesign/json (API)
| # Install 'AHTauDesign' in R: |
| install.packages('AHTauDesign', repos = c('https://xyzhao27.r-universe.dev', 'https://cloud.r-project.org')) |
This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.
Last updated from:9ac9ae672b. Checks:9 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel | OK | 149 | ||
| source / vignettes | OK | 147 | ||
| linux-release | OK | 120 | ||
| macos-release | OK | 173 | ||
| macos-oldrel | OK | 158 | ||
| windows-devel | OK | 67 | ||
| windows-release | OK | 67 | ||
| windows-oldrel | OK | 64 | ||
| wasm-release | OK | 88 |
Exports:assess_taudefault_fail_thresholdsdefault_feasibility_thresholdsoptimize_tautwostage_tau
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Assess the statistical feasibility of a proposed truncation time | assess_tau print.assess_tau |
| Default Fail thresholds for feasibility classification | default_fail_thresholds |
| Default Pass thresholds for feasibility classification | default_feasibility_thresholds |
| Feasibility-constrained utility optimization of the truncation time | optimize_tau print.optimize_tau |
| Complete two-stage truncation-time selection | plot.twostage_tau print.twostage_tau summary.twostage_tau twostage_tau |